CLOCKWISE FROM TOP LEFT: Chambers Hotel; Dylan Hotel; Stay; Greenwich Hotel.

Steps from Fifth Avenue, the Chambers Hotel is ideal for visitors with a refined eye and money to burn. It features more than 500 pieces of original artwork and a Henri Bendel personal shopper. After a retail blitz, guests can relax with inroom yoga sessions and services from Exhale Spa. Bumble and bumble bath products add a nice touch as well. Chambers Hotel, 15 West 56th Street, 212-974-5656;

Housed in the former Chemist’s Club Building, a landmark dating from 1903, the Dylan Hotel lives up to its heritage. Interiors by globally renowned architect Jeffrey Beers are a comforting relief from the ultrastark designs of some of the city’s newer developments. Beers keeps with the building’s classic Beaux Arts style while infusing his own subtle modernity. The 107 spacious guestrooms feature 11-foot ceilings, American walnut furnishings, and Carrara marble sinks. Dylan Hotel, 52 East 41st Street, 212-338-0500;

Robert De Niro has a thing for Tribeca—this we know. Thankfully, his stellar taste has translated for the best, especially in his recent development, the Greenwich Hotel. Handloomed Tibetan silk rugs and Moroccan tile accent the building’s rich architecture, and no two guest rooms are alike. The cross-cultural environment also extends to chef Agostino Sciandri’s restaurant Ago, with its signature Tuscan fare, and a Shibui spa housed under a 250-year-old Japanese farmhouse roof. The neighborhood (not to mention a raft of happy guests) thanks you, Mr. De Niro. Greenwich Hotel, 377 Greenwich Street, 212-941-8900;

Offering some of the best unobstructed views in Manhattan, the Hotel on Rivington towers some 21 stories above the historic Lower East Side. Its sleek structural design and first-rate amenities— including in-room spa services and Tempur-Pedic mattresses—impress. But for those looking to venture out, famed hairstylist Ricardo Rojas’ salon, along with acclaimed restaurant Thor and lounge 105 Riv, are all just an elevator ride away. Hotel on Rivington, 107 Rivington Street, 212-475-2600;

CLOCKWISE FROM TOP LEFT: Hudson; Kitano New York; Hotel on Rivington; Library Hotel;

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